Daily Podcast 2026-04-04
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Papers & News (40)
- [1]INTRODUCTION: This study employed metatranscriptomics to investigate the endodontic microbiome and resistome in acute apical abscesses (AAA) and asymptomatic apical periodontitis (AAP). METHODS: Root canal samples were collected from 20 patients, including 10 cases of AAA and 10 cases of AAP. RNA sequencing was conducted using the NovaSeq 6000 system. Tax...
- [2]The ongoing census of microbial life is hampered by disparate sampling across Earth's habitats, challenges in isolating uncultivated organisms, limited resolution in taxonomic marker gene amplicons and incomplete recovery of metagenome-assembled genomes. Here we quantify discoverable Bacterial and Archaeal diversity in a comprehensive, curated cross-habit...
- [3]BACKGROUND: Early weaning is a key strategy to improve lamb production efficiency; however, it inevitably compromises intestinal barrier integrity and function. This study aimed to investigate the effects of epigallocatechin (EGC) on growth performance and intestinal barrier function in weaned lambs, using metagenomics, metabolomics, and intestinal transc...
- [4]Microbes are ubiquitous on Earth, forming microbiomes that sustain macroscopic life and biogeochemical cycles. Microbial dispersal, driven by natural processes and human activities, interconnects microbiomes across habitats, yet most comparative studies focus on specific ecosystems. To study planetary microbiome structure, function, and inter-habitat inte...
- [5]BACKGROUND: Surgical resection is the primary treatment for non-small cell lung cancer (NSCLC) patients with stages I and II; however, the postoperative prognosis varies among individuals. The prognostic nutritional index (PNI) reflects the nutritional-immune status of patients, but its microbial determinants remain unclear. METHODS: PNI was analyzed in a...
- [6]The gut microbiota is a crucial component in maintaining overall human health since it has been found to influence not only metabolism but also neurobehavioral function and immunity. The extreme conditions of space, for example, cosmic radiation, microgravity, and confinement, can severely disrupt the functioning and alter the composition of gut microbiot...
- [7]BACKGROUND: The inclusion of fibre in domestic pig diets is favourable from a digestive health, environmental, and socio-economic perspective. Unlike the highly optimized formulated diets of domestic pigs, wild boars feed opportunistically, consuming a broad range of foods that consist predominantly of plant materials. Consequently, the intestinal microbi...
- [8]Type 1 diabetes (T1D) in children exhibits substantial heterogeneity in glycemic control, yet the biological mechanisms underlying this variation remain unclear. We aimed to explore endotype heterogeneity in youth with recent-onset T1D using unsupervised clustering based on multi-omics data, and to identify associated molecular signatures and underlying m...
- [9]BACKGROUND: Hirschsprung's disease (HSCR) is a congenital disorder characterized by intestinal aganglionosis. Despite evidence linking gut microbiota and immune cells to various gastrointestinal diseases, their role in HSCR pathogenesis remains poorly understood. We investigated associations between gut microbiota composition, immune cell phenotypes, and ...
- [10]Environmental DNA sequencing has revolutionized our understanding of microbial diversity and ecology. Microbiomes have now been sequenced across the entire planet-from the deep subsurface to the mountaintops-covering a myriad of hosts, biomes, and conditions. Yet, the diversity of sequencing and processing strategies hampers universal insights. MicrobeAtl...
- [11]Emerging evidence suggests a link between gut microbiota dysbiosis and osteoporosis. However, specific bacterial taxa and metabolic correlates in human osteoporosis remain poorly characterized. This study explored gut microbial profiles and serum biochemical markers in osteoporosis patients compared to non-osteoporosis individuals in Hainan, China. Fecal ...
- [12]Picocyanobacteria, represented by
- [13]BACKGROUND: Short-chain fatty acids (SCFAs), metabolic products of the gut microbiota, are important regulators of intestinal homeostasis. SCFAs exert their effects through free fatty acid receptors (FFAR), which are located on enteroendocrine cells and enteric nerves. The actions of SCFAs include the regulation of motility. How SCFAs affect enteric neuro...
- [14]This review highlights how gut microbiota regulates intestinal stem cell function. Weaning stress disrupts this balance, causing intestinal injury in piglets. However, targeted nutritional interventions can modulate the gut microbiota to restore ISC function and repair tissue damage. Understanding this microbe-ISC interaction provides new, effective strat...
- [15]Stunting, or impaired child growth due to poor nutrition and infections, is characterized by a low height-for-age and affects 48%-56% of school-aged children worldwide. It is associated with later weight gain and chronic diseases. The gut microbiome in undernourished children may increase obesity risk if they are exposed to high-calorie environments. To i...
- [16]Inflammatory bowel disease (IBD) is a chronic relapsing-remitting disorder of the gastrointestinal tract characterized by immune dysregulation, epithelial barrier dysfunction, and microbial imbalance. While bacterial dysbiosis, including depletion of short-chain fatty acid (SCFA) producers and enrichment of pathobionts, is well characterized, the gut viro...
- [17]Background: Built environment microbiome studies have identified numerous factors that shape indoor microbiomes, yet the reproducibility of these findings across buildings, timepoints, and research groups remains unclear. Differences in sequencing protocols, sampling design, and environments pose major challenges for cross-study comparisons, particularly ...
- [18]The classification of microbial communities into discrete states or community state types (CSTs) is fundamental to understanding host-microbiome interactions and their clinical implications. Traditional methods, such as the nearest-neighbor approaches, often struggle with the inherent noise, high dimensionality, and non-linear signatures of taxonomic prof...
- [19]The East Asian region, known for its high levels of human and fishery activities, experiences serious plastic pollution in the marine environment, especially in seawater and along coastlines. Wharf roaches (Ligia spp.) collected from the coast of western Japan frequently ingest expanded polystyrene (EPS), which is then excreted microplastics through their...
- [20]The human microbiota represents one of the body's most influential biological systems, engaging in constant metabolic, immunological, and neuroendocrine communication with the host. Disruption of this intricate ecosystem, or dysbiosis, has emerged as a fundamental determinant in the onset and progression of numerous chronic diseases. This review consolida...
- [21]The human gut microbiome plays a critical role in maintaining host health and homeostasis, and current literature suggests a bidirectional relationship between microbiome ecology and host well-being. DNA metabarcoding has emerged as a powerful tool for investigating microbiome imbalances (i.e., dysbiosis). While the prokaryotic microbiome has been extensi...
- [22]Pneumonia remains a leading cause of global mortality. Conventional diagnostic approaches frequently fail to distinguish microbial colonization from true infection in the lower respiratory tract, complicating clinical decision-making and contributing to antibiotic overuse. Improved diagnostic strategies are urgently needed. In this prospective, single-cen...
- [23]Intestinal barrier dysfunction contributes to the progression of inflammatory bowel disease (IBD), yet current therapies provide limited symptom relief, are associated with substantial long-term adverse effects, and exhibit high recurrence rates. Lactobacillus reuteri (L. reuteri), a probiotic with strong colonisation capacity in the gastrointestinal trac...
- [24]ETHNOPHARMACOLOGICAL RELEVANCE: Sheng Jiangsan (SJS) authorized by the Chinese Food and Drug Administration for treating wind-heat common cold, exhibits broad-spectrum antiviral activity. However, its specific antiviral and anti-inflammatory mechanisms require clarification. Gut microbiota and their metabolites play significant roles in lung disease progr...
- [25]Microcystin-LR (MC-LR) exerts detrimental effects on gut mucosal integrity and functional homeostasis in aquatic organisms. This study investigated the gut toxicity of MC-LR in grass carp exposed to 5 and 10 μg/L MC-LR through integrated histological, biochemical, molecular, microbiomics, metabolomic, and cellular analyses. MC-LR exposure caused pronounce...
- [26]INTRODUCTION AND AIMS: Oral lichen planus (OLP), a chronic inflammatory oral mucosal disorder with malignant potential, has been associated with oral microbial dysbiosis. While bacterial community alterations in OLP are well-documented, the fungal community architecture and ecological dynamics, particularly within salivary microbiota, remain poorly charac...
- [27]Atractylodes macrocephala Koidz., a traditional Chinese medicine known for "strengthening the spleen and replenishing qi", has been recognized for its gastrointestinal protective and immunomodulatory properties, suggesting a potential role in gut-brain axis regulation. This study investigated the protective effect and underlying mechanism of a purified in...
- [28]The gut microbiota is increasingly recognized as a regulator of reproductive health, yet its role in ovarian aging remains unclear. Here, we combine Mendelian randomization (MR) analysis with experimental validation to investigate the causal relationship between gut microbiota and ovarian aging. MR analysis identifies four microbial taxa significantly ass...
- [29]Short-chain fatty acids (SCFAs), derived from peroxisomal metabolism and the gut microbiota, have been proposed as key substrates to support mitochondrial oxidative phosphorylation (OXPHOS) in extrahepatic tissues such as skeletal muscle. However, the extent to which mitochondria can oxidize SCFAs (acetate, propionate and butyrate) and the ability of exer...
- [30]BACKGROUND AND AIMS: Metabolic associated steatohepatitis (MASH) is a critical stage of MAFLD, lacking effective therapies. Gut microbiota and their metabolites, particularly short-chain fatty acids (SCFAs), are increasingly recognised as modulators of hepatic metabolism and immune responses. We investigated whether Prevotella could ameliorate MASH by reg...
- [31]The gut microbiota, through its extensive metabolic repertoire, plays a pivotal role in regulating systemic physiological processes and contributing to the pathogenesis of extraintestinal diseases. Key microbial metabolites, including short-chain fatty acids (SCFAs), tryptophan derivatives, bile acids, and trimethylamine N-oxide (TMAO), act as molecular m...
- [32]Oxygen-deficient zones (ODZs) influence global nitrogen cycling as key sites for the removal of bioavailable nitrogen through denitrification and anammox. Despite their importance, many microbes and viruses in ODZs remain uncultivated, limiting our understanding of their ecological roles. This study employed Hi-C proximity linkages, combined with long and...
- [33]Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder featuring abnormal cognition, psychiatric symptoms, movement, and gastrointestinal function. It is caused by a tandem-repeat gene mutation encoding an expanded polyglutamine tract in the huntingtin protein. Our group was the first to demonstrate gut microbial disruption in both ...
- [34]Spinal cord injury (SCI), representing a devastating trauma to the central nervous system (CNS), is often accompanied by complex immune responses and metabolic dysregulation, significantly affecting patients' functional recovery and quality of life. In recent years, the gut-spinal axis, as an important pathway connecting the gut microbiome and the CNS, ha...
- [35]Microbiome community coalescence-the mixing of separate microbial communities and their environments resulting in a novel community-represents an important but understudied ecological process at the animal-environment interface. Here, we propose that animals function as "mobile bioreactors" across landscapes, ingesting environmental microbes that undergo ...
- [36]Freshwater lakes are dynamic ecosystems, with varying oxygen dynamics that influence microbiome structure, composition, and transcriptomic activity. In many freshwater studies, ecological function and abundance metrics are used to discover keystone species; however, it is well established that abundance does not equal activity. Despite the existence of lo...
- [37]Nano-Ag is increasingly detected in WWTP due to its widespread application, posing a significant threat to microbial communities responsible for wastewater treatment efficiency. Prior studies have demonstrated that quorum sensing (QS) can modulate bacterial tolerance to various environmental stressors in sludge systems. However, the feasibility and mechan...
- [38]Metaproteomics, the large-scale study of proteins from microbial communities, faces challenges in identifying species due to similarities in protein sequences across different organisms. Current methods often rely on simple counting of matches between proteins and taxa, which can lead to low accuracy. We introduce the Peptonizer2000, a new tool that uses ...
- [39]Current research on chronic atrophic gastritis (CAG) has primarily focused on intestinal flora, while the role of gastric juice microecology remains poorly understood. This study investigated whether alterations in gastric juice microbiota and bile acid (BA) profiles are associated with CAG under microbiota perturbation. A CAG rat model was designed by a ...
- [40]BACKGROUND: Altered gut microbiota composition has been implicated in the development of hypertension. Evidence suggests bacterial products and metabolites can enter circulation, act on peripheral tissues, and modulate blood pressure (BP). We identified extracellular vesicles (EVs) of bacterial origin (bacterial extracellular vesicles [bEVs]) in the circu...