Bacteria in metastatic sites: Unveiling hidden players in cancer progression

Image credit: Cancer Cell

Abstract

Bacteria exhibit key features of cancer metastasis, such as motility, invasion, and modulation of the tumor microenvironment. They migrate through lymphatic and blood systems, invade metastatic tissues, and alter local microenvironments to support metastatic growth. Bacteria also shape the tumor microenvironment, affecting immune responses and inflammation, which influence tumor progression and therapy response. While they hold therapeutic potential, challenges like contamination and complex characterization persist, necessitating advanced sequencing and research for clinical application.

Publication
Cancer Cell
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Verónica Lloréns-Rico
Verónica Lloréns-Rico
Junior Group Leader, Systems Biology of Host-Microbiome Interactions lab

My research interests include bacterial gene regulation and the human microbiome.